Many of the alternative refrigerants to hydrochlorofluorocarbons (HCFCs) have particular characteristics in terms of toxicity, flammability and high pressure which are different from those used previously. It is therefore important that the refrigeration and air-conditioning industry adapts to both the technical and safety issues concerning these refrigerants. This publication provides an overview of the alternatives, their general characteristics and their application in the context of the safety issues. It provides guidance for National Ozone Units (NOUs) and other interested parties in developing countries on how they can advise and assist their national stakeholders in the selection and implementation of alternative refrigerants.